BrainWaves: A Neurology Podcast

#75 Glioblastoma

BrainWaves: A Neurology Podcast

The most common primary brain tumor that occurs in adults, glioblastoma multiforme comes with a life expectancy shorter than practically every other form of cancer. But thanks to novel treatment strategies, advanced neuroimaging, and biomarker research, we are learning more and more how to improve the survival and the quality of life with patients who suffer from this terrible illness.

Produced by James E. Siegler and Neena Cherayil. Music by Axle, Coldnoise, Josh Woodward, and Kelly Latimer. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making.

REFERENCES

  1. Grady, D “Glioblastoma, John Mccain’s Form of Brain Cancer, Carries Troubling Prognosis” The New York Times <https://www.nytimes.com/2017/07/20/health/john-mccain-brain-cancer.html>
  2. Scutti, S “Sen John McCain has aggressive brain tumor, surgically removed” CNN <http://www.cnn.com/2017/07/19/health/gupta-mccain-glioblastoma/index.html>
  3. Gately L, et al. Life beyond a diagnosis of glioblastoma: a systematic review of the literature. J Cancer Surviv (2017).
  4. Thakkar JP, et al. Epidemiologic and Molecular Prognostic Review of Glioblastoma. Cancer epidemiology, biomarkers & prevention (2014).
  5. Louis DN, et al. “The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A Summary” Acta Neuropathologica (2016) 6: 803-820.
  6. Stupp R, et al. MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma. N Engl J Med (2005).
  7. Stupp R, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. The Lancet Oncology (2009).
  8. Weller M and Wick W. Neuro-oncology in 2013: improving outcome in newly diagnosed malignant glioma. Nature reviews Neurology. 2014;10:68-70.

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